Global assessments of overall urinary function and symptoms were also performed by investigators who were blinded to patient treatment assignment. Statistically significant differences were not found in the verapamil level with and without Terazosin. Phenylephrine; Promethazine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. macrobid
Tikosyn overdose was rare in clinical studies; there were two reported cases of Tikosyn overdose in the oral clinical program. One patient received very high multiples of the recommended dose 28 capsules was treated with gastric aspiration 30 minutes later, and experienced no events. One patient inadvertently received two 500 mcg doses one hour apart and experienced ventricular fibrillation and cardiac arrest 2 hours after the second dose. Thiopental: Concurrent use of thiopental and alpha-blockers or antihypertensive agents increases the risk of developing hypotension. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Ethinyl Estradiol; Ethynodiol Diacetate: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using terazosin while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use terazosin, check with your doctor. Discuss any possible risks to your baby.
Dofetilide is eliminated in the kidney by cationic secretion. Inhibitors of renal cationic secretion are contraindicated with Tikosyn. Kidney function declines as you grow older. This medication is removed by the kidneys. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
LDL, total cholesterol, and triglyceride concentrations. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. You should avoid driving or hazardous tasks for 12 hours after the first dose, after your dose is increased, and when this medication is restarted after it has been stopped. Limit beverages. The information contained in the Truven Health Micromedex products as delivered by Drugs. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses. If you take too much Tikosyn, call your doctor or go to the nearest hospital emergency room right away. Take your Tikosyn capsules with you to show to the doctor. The usual recommended dose of Tikosyn is 500 mcg BID, as modified by the dosing algorithm described below. For consideration of a lower dose, see below. Both studies randomized patients to placebo or to doses of Tikosyn 125 mcg, 250 mcg, 500 mcg, or in one study a comparator drug, given twice a day these doses were lowered based on calculated creatinine clearance and, in one of the studies, for QT interval or QTc. Risperidone: Risperidone may induce orthostatic hypotension and thus enhance the hypotensive effects of antihypertensive agents. Lower initial doses or slower dose titration of risperidone may be necessary in patients receiving antihypertensive agents concomitantly.
National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC VI. Bethesda, MD: National Institutes of Health; 1997 Nov. NIH publication No. 98-4080. Administer once daily at bedtime. Highest dose 10 mg shown. PROTECT FROM MOISTURE AND HUMIDITY. How should I take terazosin Hytrin? During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. In volunteers with varying degrees of renal impairment and patients with arrhythmias, the clearance of dofetilide decreases with decreasing creatinine clearance. As a result, and as seen in clinical studies, the half-life of dofetilide is longer in patients with lower creatinine clearances. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Fospropofol: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. The ALLHAT collaborative research group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial ALLHAT. JAMA. The incidence of treatment-emergent adverse events has been ascertained from clinical trials conducted worldwide. All adverse events reported during these trials were recorded as adverse reactions. The incidence rates presented below are based on combined data from six placebo-controlled trials involving once-a-day administration of Terazosin at doses ranging from 1 to 20 mg. Table 1 summarizes those adverse events reported for patients in these trials when the incidence rate in the Terazosin group was at least 1%, and was greater than that for the placebo group, or where the reaction is of clinical interest. dutasteride
Terazosin Capsules, USP Can Cause a Sudden Drop in Blood Pressure After the VERY FIRST DOSE. You may feel dizzy, faint, or “light-headed” particularly after you get up from bed or from a chair. Please read this leaflet before you start taking terazosin hydrochloride capsules. Also, read it each time you get a new prescription. This is a summary and should NOT take the place of a full discussion with your doctor who has additional information about terazosin hydrochloride. You and your doctor should discuss terazosin hydrochloride and your condition before you start taking it and at your regular check-ups. Andersson KE. Current concepts in the treatment of disorders of micturition. Drugs. What is terazosin Hytrin? Pfizer Roerig. Cardura doxazosin mesylate tablets prescribing information. New York, NY; 1994 Dec. Older adults may be more sensitive to the side effects of this drug, especially dizziness, fainting, and low blood pressure when getting up from a sitting or lying position. These side effects can increase the risk of falling. Patients should be made aware of the possibility of syncopal and orthostatic symptoms, especially at the initiation of therapy, and to avoid driving or hazardous tasks for 12 hours after the first dose, after a dosage increase and after interruption of therapy when treatment is resumed. They should be cautioned to avoid situations where injury could result should syncope occur during initiation of terazosin therapy. They should also be advised of the need to sit or lie down when symptoms of lowered blood pressure occur, although these symptoms are not always orthostatic, and to be careful when rising from a sitting or lying position. If dizziness, lightheadedness, or palpitations are bothersome they should be reported to the physician, so that dose adjustment can be considered. Possible rapid fall in BP and exacerbation of postural effects. May consider combined therapy with an α 1-adrenergic blocker and 5α-reductase inhibitor for men with bothersome moderate to severe BPH and demonstrable prostatic enlargement. 59 Has been more effective than therapy with either drug alone in preventing long-term BPH symptom progression. 59 Men at risk for BPH progression are most likely to benefit from combination therapy. Articaine; Epinephrine: Sympathomimetics, such as epinephrine, can antagonize the effects of alpha-blockers when administered concomitantly. Patients receiving alpha-blockers can exhibit a decreased pressor response to epinephrine, resulting in an increased risk of developing hypotension and tachycardia. Blood pressure should be monitored closely. Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. Do not share Terazosin capsules with anyone else; it was prescribed only for you. You should see an effect on your symptoms in 2 to 4 weeks. So, you will need to continue seeing your doctor to check your progress regarding your BPH and to monitor your blood pressure in addition to your other regular checkups. abla.info divalproex
Tikosyn can cause serious side effects, including a type of abnormal heartbeat called Torsade de Pointes, which can lead to death. See "What is the most important information I should know about Tikosyn? Chlorpheniramine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Terazosin hydrochloride works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. If Tikosyn needs to be discontinued to allow dosing of other potentially interacting drugs a washout period of at least two days should be followed before starting the other drugs. Levomilnacipran: Levomilnacipran has been associated with an increase in blood pressure. The effectiveness of antihypertensive agents, including alpha-blockers, may be diminished during concurrent use of levomilnacipran. It is advisable to monitor blood pressure if the combination is necessary. Drospirenone; Ethinyl Estradiol: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. It is insoluble in water; sparingly soluble in ethanol; and soluble in butanol. If you are taking this drug for the first time, not take more than 1 milligram to start. Terazosin helps relieve the symptoms of BPH. It does NOT change the size of the prostate, which may continue to grow. However, a larger prostate does not necessarily cause more or worse symptoms. Keep Tikosyn in a tightly closed container. Break off suppository from the plastic strip. Terazosin capsules, USP are also indicated for the treatment of hypertension. Terazosin capsules, USP can be used alone or in combination with other antihypertensive agents such as diuretics or beta-adrenergic blocking agents. Of the total number of patients in clinical studies of Tikosyn, 46% were 65 to 89 years old. No overall differences in safety, effect on QTc, or effectiveness were observed between elderly and younger patients. Other side effects you could have while taking terazosin hydrochloride include drowsiness, blurred or hazy vision, nausea, or "puffiness" of the feet or hands. Discuss any unexpected effects you notice with your doctor. suprax town center
Increased fetal resorptions, decreased fetal weight and an increased number of supernumerary ribs were observed in offspring of rabbits dosed with 60 times the maximum recommended human dose. These findings in both species were most likely secondary to maternal toxicity. There are no adequate and well-controlled studies in pregnant women and the safety of Terazosin in pregnancy has not been established. Terazosin capsules are not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Amobarbital: Concurrent use of amobarbital with antihypertensive agents may lead to hypotension. Monitor for decreases in blood pressure during times of coadministration. Khoury AF, Kaplan NM. α-Blocker therapy of hypertension. JAMA. Dispense in tight containers USP. These medications have specific and limited indications based on the cause and categorization of incontinence. Patients should be assessed periodically for medication effects on urinary incontinence as well as lower urinary tract symptoms and treatment tolerability. Diethylpropion: Diethylpropion has vasopressor effects and may limit the benefit of alpha-blockers. Although leading drug interaction texts differ in the potential for an interaction between diethylpropion and this group of antihypertensive agents, these effects are likely to be clinically significant and have been described in hypertensive patients on these medications. Cabergoline: Cabergoline has minimal affinity for adrenergic receptors; however, it has been associated with hypotension in some instances. Cabergoline should be used cautiously in those receiving antihypertensive agents or other medications known to cause hypotension.
Alemtuzumab: Alemtuzumab may cause hypotension. Careful monitoring of blood pressure and hypotensive symptoms is recommended especially in patients with ischemic heart disease and in patients on antihypertensive agents. Acetaminophen; Dichloralphenazone; Isometheptene: Sympathomimetics can antagonize the antihypertensive effects of adrenergic agonists when administered concomitantly. Patients should be monitored for loss of blood pressure control. Sildenafil: Patients should be stable on alpha-blocker therapy before initiating therapy with sildenafil or other phosphodiesterase type 5 PDE5 inhibitors; the lowest dose should be used to initiate therapy. Conversely, patients already receiving an optimized dose of a PDE5 inhibitor should be started on the lowest dose of an alpha-blocker; increases in the alpha-blocker dose should be done in a stepwise fashion. Using sildenafil and alpha-blockers together may reduce blood pressure significantly in some patients and may lead to symptomatic hypotension. PDE5 inhibitors and alpha blockers are both vasodilators with blood pressure lowering effects. Sildenafil doses greater than 25 mg should not be taken within 4 hours of taking alpha-blockers. In the DIAMOND studies, although Torsade de Pointes occurred more frequently in the Tikosyn-treated patients see Tikosyn, given with an initial 3-day hospitalization and with dose modified for reduced creatinine clearance and increased QT interval, was not associated with an excess risk of mortality in these populations with structural heart disease in the individual studies or in an analysis of the combined studies. The presence of atrial fibrillation did not affect outcome. Carbetapentane; Diphenhydramine; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Rituximab: Patients should not take antihypertensive agents 12 hours prior to rituximab infusions due to the possibility of hypotension occurring during the rituximab infusion. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Geriatric patients may be more sensitive to the hypotensive and adverse effects dry mouth and drowsiness of terazosin. Monitor older adult patients closely. According to the Beers Criteria, terazosin is considered a potentially inappropriate medication PIM for use in geriatric patients and should be avoided as routine treatment of hypertension in this population due to the high risk of orthostatic hypotension and the availability of alternative agents with a superior benefit to risk profile. In addition, the Beers expert panel recommends avoiding terazosin in geriatric patients with syncope due to an increased risk of orthostatic hypotension or bradycardia, and also avoiding terazosin in elderly females with urinary incontinence, regardless of cause or type, because aggravation of incontinence may occur. The federal Omnibus Budget Reconciliation Act OBRA regulates medication use in residents of long-term care facilities LTCFs. According to the OBRA guidelines, antihypertensive regimens should be individualized to achieve the desired outcome while minimizing adverse effects. Antihypertensives may cause dizziness, postural hypotension, fatigue, and there is an increased risk for falls. Terazosin can cause significant hypotension and syncope during the first few doses; therefore, the dose should be administered at bedtime initially, and the drug slowly titrated as needed. There are many drug interactions that can potentiate the effects of antihypertensives. Some agents require a gradual taper to avoid adverse consequences caused by abrupt discontinuation. Tikosyn has not been shown to be effective in patients with paroxysmal atrial fibrillation. Terazosin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use it for other health conditions. If Terazosin capsules administration is discontinued for several days, therapy should be reinstituted using the initial dosing regimen. Yellow 6 Imprinting ink: iron oxide black, shellac, n-butyl alcohol, isopropyl alcohol, propylene glycol, and ammonium hydroxide Listed trademarks are the property of their respective owners. Bakris GL, Williams M, Dworkin L et al. Preserving renal function in adults with hypertension and diabetes: a consensus approach. Am J Kidney Dis. Nonsteroidal antiinflammatory drugs: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Doses of antihypertensive medications may require adjustment in patients receiving concurrent NSAIDs. NSAIDs, to varying degrees, have been associated with an elevation in blood pressure. This effect is most significant in patients receiving concurrent antihypertensive agents and long-term NSAID therapy. NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain. Patients who rely upon renal prostaglandins to maintain renal perfusion may have acute renal blood flow reduction with NSAID usage. Elderly patients may be at increased risk of adverse effects from combined long-term NSAID therapy and antihypertensive agents, especially diuretics, due to age-related decreases in renal function and an increased risk of stroke and coronary artery disease. Urinary frequency, urinary incontinence primarily reported in postmenopausal women, urinary tract infection. accutane drug price uk
Terazosin capsules are contraindicated in patients known to be hypersensitive to Terazosin hydrochloride. Terazosin capsules, USP, for oral administration, are supplied in four dosage strengths containing Terazosin hydrochloride, USP equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of Terazosin. Inactive ingredients: Crospovidone, lactose monohydrate magnesium stearate, and microcrystalline cellulose. May contain corn starch. Tizanidine: Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Caution is advised when tizanidine is to be used in patients receiving concurrent antihypertensive therapy. There was no clinically significant alteration in the pharmacokinetics of dofetilide in volunteers with mild to moderate hepatic impairment Child-Pugh Class A and B compared to age- and weight-matched healthy volunteers. Patients with severe hepatic impairment were not studied. Trazodone: Due to additive hypotensive effects, patients receiving antihypertensive agents concurrently with trazodone may have excessive hypotension. Decreased dosage of the antihypertensive agent may be required when given with trazodone. Pull the plastic completely apart at the notched end. Kaplan NM. Choice of initail therapy for hypertension. JAMA. Administer once daily or, if needed for optimal BP control, in 2 divided doses at 12-hour intervals. Psaty BM, Smith NL, Siscovich DS et al. Health outcomes associated with antihypertensive therapies used as first-line agents: a systematic review and meta-analysis. JAMA. Bortezomib: Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their blood pressure and dosage adjustment of their medication. During clinical trials of bortezomib, hypotension was reported in roughly 12 percent of patients. price celebrex do
Some terazosin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Iloprost: The effects of iloprost on blood pressure may be additive to those of antihypertensive agents. Lower doses of the antihypertensive may be needed with combined treatment. Terazosin reduces blood pressure in both the supine and standing positions, with more dramatic effects on diastolic blood pressure. These effects are similar to those of prazosin. There is no change in the patient's cardiac output or heart rate, and the response to exercise remains essentially the same. Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have "water diabetes" diabetes insipidus or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration. This makes the stool bigger, which gives you the urge to pass the stool. Regular use of bulking agents is safe and often lets you have more stools. Sperzel WD, Glassman HN, Jordan DC et al. Overall safety of terazosin as an antihypertensive agent. Am J Med. Nitroprusside: Additive hypotensive effects may occur when nitroprusside is used concomitantly with other antihypertensive agents. Dosages should be adjusted carefully, according to blood pressure. It is important to continue this medication even if you do not have any symptoms. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Do not stop using this medication without consulting your doctor. Ethanol: Ethanol interacts with antihypertensive agents by potentiating their hypotensive effect. Wing LMH, Reid CM, Ryan P, et al, for Second Australian National Blood Pressure Study Group. A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for hypertension in the elderly. N Engl J Med. Where can I get more information? The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences events reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of Terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the Terazosin group was at least 5%, where the prevalence rate for the Terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest. Terazosin is also used in men to treat the symptoms of an enlarged prostate benign prostatic hyperplasia-BPH. It does not shrink the prostate, but it works by relaxing the muscles in the prostate and part of the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently including during the middle of the night. travatan
The concomitant use of hydrochlorothiazide alone or in combinations such as with triamterene with Tikosyn is contraindicated see because this has been shown to significantly increase dofetilide plasma concentrations and QT interval prolongation. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. Tikosyn is also contraindicated in patients with a known hypersensitivity to the drug. Ethinyl Estradiol; Desogestrel: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. After correction for renal function, clearance of dofetilide is not related to age.
Reduction of urinary obstruction and relief of associated manifestations in patients with symptomatic BPH. Co-Enzyme Q10, Ubiquinone: Co-enzyme Q10, ubiquinone CoQ10 may lower blood pressure. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Patients who choose to take CoQ10 concurrently with antihypertensive medications should receive periodic blood pressure monitoring. Patients should be advised to inform their prescriber of their use of CoQ10. Dobutamine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. The dose of terazosin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of terazosin. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. cost of albuterol at boots
Priapism reported rarely; may lead to permanent impotence if not treated promptly. 1 48 49 See Advice to Patients. Keep Tikosyn away from moisture and humidity. Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Tikosyn. See the end of this leaflet for a complete list of ingredients in Tikosyn. All medicines may cause side effects, but many people have no, or minor, side effects. Acetaminophen; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Upjohn Company. Caverject alprostadil injection for intracavernosal use prescribing information. Kalamazoo, MI; 1995 Jul. Do not keep outdated medicine or medicine no longer needed. Alprostadil: The concomitant use of systemic alprostadil injection and antihypertensive agents, such as terazosin, may cause additive hypotension. Caution is advised with this combination. Systemic drug interactions with the urethral suppository MUSE or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral venous circulation following administration. In those men with significant corpora cavernosa venous leakage, hypotension might be more likely. Use caution with in-clinic dosing for erectile dysfunction ED and monitor for the effects on blood pressure. In addition, the presence of medications in the circulation that attenuate erectile function may influence the response to alprostadil. However, in clinical trials with alprostadil intracavernous injection, anti-hypertensive agents had no apparent effect on the safety and efficacy of alprostadil. It can also occur if you stop taking the drug and then re-start treatment. Importance of advising patients of other important precautionary information. 1 See Cautions. is ordering metoprolol online safe
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Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. The rash was accompanied by mild fever, asthenia, and intense pruritus. The patient was on no other medications. Hematologic and histopathologic studies suggested a drug reaction. Terazosin was discontinued. Two weeks following oral methylprednisolone 40 mg daily and emollients, symptoms had resolved completely. Estradiol: Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored to confirm that the desired antihypertensive effect is being obtained.
If you use more than 1 dose daily and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Take Tikosyn exactly as your doctor tells you. Chapple CR, Christmas TJ, Milroy EJ. A twelve-week placebo-controlled study of prazosin in the treatment of prostatic obstruction. Urol Int. Weber MA, Schiffrin EL, White WB et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Clin Hypertens Greenwich.
AFl after drug-induced or electrical cardioversion. Only 4% of 354 patients from a multicenter trial complained of general abdominal pain or diarrhea within the first 90 days of therapy. Terazosin hydrochloride relaxes the tightness of a certain type of muscle in the prostate and at the opening of the bladder. Terazosin has been studied in 1222 men with symptomatic BPH. In three placebo-controlled studies, symptom evaluation and uroflowmetric measurements were performed approximately 24 hours following dosing. Symptoms were quantified using the Boyarsky Index. The questionnaire evaluated both obstructive hesitancy, intermittency, terminal dribbling, impairment of size and force of stream, sensation of incomplete bladder emptying and irritative nocturia, daytime frequency, urgency, dysuria symptoms by rating each of the 9 symptoms from 0 to 3, for a total score of 27 points.
Renal function and QTc should be re-evaluated every three months or as medically warranted. If QTc exceeds 500 milliseconds 550 msec in patients with ventricular conduction abnormalities Tikosyn therapy should be discontinued and patients should be carefully monitored until QTc returns to baseline levels. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.